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Review
. 2022 Sep;49(9):8883-8893.
doi: 10.1007/s11033-022-07365-6. Epub 2022 May 17.

Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing

Yun Xiao  1   2 , Ying Tang  3 , Xiao Shu  4 , Jinshuo Zhu  1 , Xinan Wu  4 , Yuan Zhang  5
Affiliations
Review

Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing

Yun Xiao et al. Mol Biol Rep. 2022 Sep.

Abstract

Destroying the integrity of the skin may causes disability and even death from injury or illness. Wound healing is a core mechanism to maintain skin barrier function. Milk fat-globule epidermal growth factor 8 (MFG-E8) is a key factor in wound healing and is involved in regulating blood coagulation, mediating macrophage uptake of apoptotic cells, shifting macrophages from an inflammatory to an anti-inflammatory phenotype, promoting angiogenesis, enhancing vascular endothelial growth factor (VEGF) signaling, and assisting wound tissue perfusion. However, these abilities are dysregulated in pathological conditions, such as glucose disorders and ischemic injury. Restricted application of exogenous MFG-E8 can restore function and play a beneficial role in cutaneous wound healing.

Keywords: Inflammation; MFG-E8 accelerates impaired skin wound healing of diabetes and Ischemia/Reperfusion Injury; MFG-E8 is involved in hemostasis; Proliferation and maturation of wound healing.

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