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. 2022 May 17;15(1):19.
doi: 10.1186/s12245-022-00423-7.

Sudden quadriparesis after non-overdose local anesthesia

Wei-Chen Chen  1 , Hsien-Yi Chen  1   2 , Te-I Weng  3   4   5 , Chun-Kuei Chen  6   7
Affiliations

Sudden quadriparesis after non-overdose local anesthesia

Wei-Chen Chen et al. Int J Emerg Med. .

Abstract

Background: A well-known anesthetic, lidocaine is the most widely used local anesthetic. Local anesthetic systemic toxicity (LAST) is a life-threatening event with common and prominent presentations of central nervous system (CNS) toxicity and cardiovascular toxicity. The most frequent and prominent early warning signs and symptoms of LAST are central nervous system symptoms. While rare, cases quadriparesis after the administration of lidocaine has been reported.

Case presentation: In this paper, we report a very rare case of quadriparesis after local anesthesia administration for vocal cord cyst-removal surgery, which dramatically improved after treatment. LAST can occur during various routes of lidocaine administration, such as local spray. A possible mechanism of our case could be the local diffusion of lidocaine to the spinal cord, which caused the symptoms to mimic anterior cord syndrome.

Conclusions: Our case presented a favorable outcome following the administration of intravenous lipid emulsion (ILE) for non-over dose local anesthetic drug induced spinal cord inhibition symptoms. These findings highlight the need for further research on the use of ILE to reverse LAST and other adverse effects of local anesthetics.

Keywords: Lipid emulsion; Local anesthetic systemic toxicity; Quadriparesis; Vocal cord cyst-removal surgery.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Vadi MG, Patel N, Stiegler MP. Local anesthetic systemic toxicity after combined psoas compartment-sciatic nerve block: analysis of decision factors and diagnostic delay. Anesthesiology. 2014;120(4):987–996. doi: 10.1097/ALN.0000000000000154. - DOI - PubMed
    1. Yaddanapudi S. Prevention of local anesthetic systemic toxicity. J Anaesthesiol Clin Pharmacol. 2011;27(4):438–439. doi: 10.4103/0970-9185.86566. - DOI - PMC - PubMed
    1. El-Boghdadly K, Pawa A, Chin KJ. Local anesthetic systemic toxicity: current perspectives. Local Reg Anesth. 2018;11:35–44. doi: 10.2147/LRA.S154512. - DOI - PMC - PubMed
    1. Gitman M, Fettiplace MR, Weinberg GL, Neal JM, Barrington MJ. local anesthetic systemic toxicity: a narrative literature review and clinical update on prevention, diagnosis, and management. Plast Reconstr Surg. 2019;144(3):783–795. doi: 10.1097/PRS.0000000000005989. - DOI - PubMed
    1. El-Boghdadly K, Chin KJ. Local anesthetic systemic toxicity: continuing professional development. Can J Anaesth. 2016;63(3):330–349. doi: 10.1007/s12630-015-0564-z. - DOI - PubMed

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