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. 2013 Jan 15;2(1):14-18.
doi: 10.1021/mz3005814. Epub 2012 Dec 14.

Bioconjugation Using Thiols: Old Chemistry Rediscovered to Connect Polymers with Nature's Building Blocks

Martina H Stenzel  1
Affiliations

Bioconjugation Using Thiols: Old Chemistry Rediscovered to Connect Polymers with Nature's Building Blocks

Martina H Stenzel. ACS Macro Lett. .

Abstract

Various pathways to bioconjugates based on thiol chemistry are discussed. Thiol-halogeno, thiol-parafluoro, thiol-ene, thiol-yne, thiol-vinylsulfone and thiol-vinyl sulfone, thiol-maleimide, thiol-bisulfone, and thiol-pyridyl disulfide are well-established synthetic routes discovered in recent years as tools to marry polymers with biomolecules such as carbohydrates, proteins, peptide, DNA, antibodies, or other building blocks from nature.

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