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Case Reports
. 2022 Apr 16;10(11):3573-3578.
doi: 10.12998/wjcc.v10.i11.3573.

Qingchang decoction retention enema may induce clinical and mucosal remission in left-sided ulcerative colitis: A case report

Pei-Han Li  1 , Yu Tang  2 , Hong-Zhu Wen  3
Affiliations
Case Reports

Qingchang decoction retention enema may induce clinical and mucosal remission in left-sided ulcerative colitis: A case report

Pei-Han Li et al. World J Clin Cases. .

Abstract

Background: Ulcerative colitis (UC) is a chronic autoimmune disease characterized by relapsing-remitting abdominal pain, diarrhea, mucopurulent discharge and rectal bleeding. To date, the etiology of the disease remains unknown; therefore, medical therapy is not yet available. Left-sided UC is mainly treated with oral and topical mesalazine. However, due to its modest clinical effect, endoscopic mucosal remission is not achieved in all patients.

Case summary: A 44-year-old man presented to Longhua Hospital with a history of left-sided UC for more than 6 years and slight bloody diarrhea over time. Endoscopy suggested hyperemia, edema, and erosive mucosa involving the rectum and sigmoid colon. The Traditional Chinese medicine Qingchang decoction (QCD) enema treatment was initiated once a day combined with a previous standard dose of mesalazine for 8 wk, and rectal bleeding ceased after 4 wk of treatment. Another QCD enema treatment was provided after symptom relapse due to drug withdrawal for nearly 6 mo. At the 2-mo follow-up, the colonoscopy results indicated mucosal healing with no erosion or ulcers.

Conclusion: The Chinese formula QCD retention enema represents a potential treatment for left-sided UC with predominant rectal bleeding to achieve clinical and mucosal remission.

Keywords: Case report; Chinese formulas; Qingchang decoction enema; Qingchang suppository; Ulcerative colitis.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Endoscopic images before Qingchang decoction retention enema treatment. A: Colonoscopy image showing hyperemia, edema, erosions, and friability in the sigmoid colon; B: Colonoscopy image showing hyperemia, edema, erosions, and friability in the rectum.
Figure 2
Figure 2
Endoscopic images after Qingchang decoction retention enema treatment. A: Colonoscopy image showing normal mucosa in the sigmoid colon; B: Colonoscopy image showing patchy hyperemia in the rectum.
See this image and copyright information in PMC

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