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Editorial
. 2022 May 1;23(5):385-389.
doi: 10.1097/PCC.0000000000002943. Epub 2022 May 5.

Resuscitation With Vitamins C and B1 in Pediatric Sepsis-Hold on to Your "HAT"

Nilesh M Mehta  1   2   3
Affiliations
Editorial

Resuscitation With Vitamins C and B1 in Pediatric Sepsis-Hold on to Your "HAT"

Nilesh M Mehta. Pediatr Crit Care Med. .
No abstract available

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Conflict of interest statement

The author has disclosed that he does not have any potential conflicts of interest.

References

    1. Moskowitz A, Andersen LW, Huang DT, et al.: Ascorbic acid, corticosteroids, and thiamine in sepsis: A review of the biologic rationale and the present state of clinical evaluation. Crit Care. 2018; 22:283
    1. Marik PE, Khangoora V, Rivera R, et al.: Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study. Chest. 2017; 151:1229–1238
    1. Coloretti I, Biagioni E, Venturelli S, et al.: Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study. J Crit Care. 2020; 59:37–41
    1. Fowler AA 3rd, Truwit JD, Hite RD, et al.: Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA. 2019; 322:1261–1270
    1. Fujii T, Luethi N, Young PJ, et al.; VITAMINS Trial Investigators: Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial. JAMA. 2020; 323:423–431

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