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. 2022 Jun 16;386(24):2337-2339.
doi: 10.1056/NEJMc2202879. Epub 2022 May 18.

Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults

Patrick E Brown  1 , Sze Hang Fu  1 , Aiyush Bansal  1 , Leslie Newcombe  1 , Karen Colwill  2 , Geneviève Mailhot  2 , Melanie Delgado-Brand  2 , Anne-Claude Gingras  2 , Arthur S Slutsky  1 , Maria Pasic  1 , Jeffrey Companion  1 , Isaac I Bogoch  3 , Ed Morawski  4 , Teresa Lam  4 , Angus Reid  4 , Prabhat Jha  5 ; Ab-C Study Collaborators; Ab-C Study Investigators
Collaborators, Affiliations

Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults

Patrick E Brown et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Spike Protein Titers for IgG Antibody in Canadian Adults and the Age-Specific Cumulative Incidence of Infection before and during the Omicron BA.1/1.1 Variant Wave.
Shown are spike titers, which represent the relative ratios of IgG antibody values against the spike protein to the control samples (Section S1 in the Supplementary Appendix), with stratification according to infection and vaccination status in Canadian adults (Panel A) and the age-specific cumulative incidence of infection in each stratum of previous infection and vaccination before and during the omicron BA.1/1.1 variant wave (Panel B). Dots represent participants who received their last dose of vaccine (or were unvaccinated) at least 1 month before dried-blood-spot samples were obtained. (A total of 3344 participants had complete information available as of the time of analyses after the exclusion of 21 low-quality samples.) In the box-and-whisker plots, the solid line represents the median, the box represents the interquartile range, and the whiskers represent 1.5 times the interquartile range. Results with the use of the receptor-binding domain antigen were similar to those with the spike protein (Fig. S3). The cumulative incidences of Canadian adults in each category of vaccination and infection (assessed on the basis of nucleocapsid protein positivity or molecular or antigen rapid testing) were drawn from the groups of 3481 participants in phase 3 (before the omicron BA.1/1.1 wave) and 4032 participants in phase 4 (during the omicron BA.1/1.1 wave, with a reference period starting December 1, 2021) for whom complete testing, vaccination, and antibody data were available by the time of the analyses. The first column in the overall and age-specific sets represents the antibody and viral test positivity for the entire period before the omicron BA.1/1.1 wave, and the second column represents the values during the omicron BA.1/1.1 wave. Percentages may not total 100 because of rounding.
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References

    1. Ritchie H, Mathieu E, Rodés-Guirao L, et al. Coronavirus pandemic (COVID-19). Our World In Data, 2022. (https://ourworldindata.org/coronavirus).
    1. Tang X, Sharma A, Pasic M, et al. Assessment of SARS-CoV-2 seropositivity during the first and second viral waves in 2020 and 2021 among Canadian adults. JAMA Netw Open 2022;5(2):e2146798-e2146798. - PMC - PubMed
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Supplementary concepts

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