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Editorial
. 2022 Sep 1;206(5):526-528.
doi: 10.1164/rccm.202205-0884ED.

Double Jeopardy: Precapillary Pulmonary Hypertension Increases the Risk of Hospitalization and Death from COVID-19

George A Alba  1
Affiliations
Editorial

Double Jeopardy: Precapillary Pulmonary Hypertension Increases the Risk of Hospitalization and Death from COVID-19

George A Alba. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Patients with precapillary pulmonary hypertension (PH) are at increased risk of hospitalization and in-hospital mortality from coronavirus disease (COVID-19). Patients with underlying cardiopulmonary disease are at increased risk of adverse clinical outcomes from COVID-19, but observational data are conflicting regarding the risk posed to patients with PH. In this issue of the Journal, Montani and colleagues report results from the largest national prospective cohort study of patients with PH who received diagnoses of COVID-19, wherein they observed high rates of hospitalization (60%) and in-hospital mortality (41.3%). Patients at highest risk of dying were male, older, had more severe baseline PH, and were more medically comorbid. Pulmonary vasodilator therapies did not protect against in-hospital death, but patients on baseline anticoagulation were more likely to survive their hospitalization. This study establishes that patients with precapillary PH are at increased risk of adverse clinical outcomes from COVID-19, underscoring the public health importance of preventive measures in this high-risk population. CTEPH = chronic thromboembolic pulmonary hypertension; PAH = pulmonary arterial hypertension. Illustration by Jill Gregory.
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Comment on

  • COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study.
    Montani D, Certain MC, Weatherald J, Jaïs X, Bulifon S, Noel-Savina E, Nieves A, Renard S, Traclet J, Bouvaist H, Riou M, de Groote P, Moceri P, Bertoletti L, Favrolt N, Guillaumot A, Jutant EM, Beurnier A, Boucly A, Ebstein N, Jevnikar M, Pichon J, Keddache S, Preda M, Roche A, Solinas S, Seferian A, Reynaud-Gaubert M, Cottin V, Savale L, Humbert M, Sitbon O; French PH Network PULMOTENSION Investigators. Montani D, et al. Am J Respir Crit Care Med. 2022 Sep 1;206(5):573-583. doi: 10.1164/rccm.202112-2761OC. Am J Respir Crit Care Med. 2022. PMID: 35549842 Free PMC article.

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