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. 2022 May 16:20:eAO6781.
doi: 10.31744/einstein_journal/2022AO6781. eCollection 2022.

In-hospital outcomes in preterm and small-for-gestational-age newborns: a cohort study

Lo-Ruama Pereira Costa  1 , Gleise Aparecida Moraes Costa  1 , Cristina Ortiz Sobrinho Valete  2 , José Kleber Kobol Machado  1 , Mariliza Henrique da Silva  1
Affiliations

In-hospital outcomes in preterm and small-for-gestational-age newborns: a cohort study

Lo-Ruama Pereira Costa et al. Einstein (Sao Paulo). .

Abstract

Objective: To compare in-hospital outcomes between small-for-gestational-age and appropriate-for-gestational-age preterm neonates who needed intensive care.

Methods: A retrospective cohort study with preterm newborns, from January to December 2017. The results are presented as median, frequency, and odds ratio. Numerical variables were compared using the Wilcoxon test. Categorical variables were compared using the χ2 test. We considered p<0.05 as significant.

Results: Out of 129 preterm newborns included, 20.9% were small-for-gestational-age. Median gestational age was 31 2/7 weeks, birthweight was 1,450g, and length of hospital stay was 39 days. Preterm small-for-gestational-age newborns presented a higher chance of peri-intraventricular hemorrhage (odds ratio of 3.23; p=0.02), retinopathy of prematurity (odds ratio of 2.78 p=0.02), patent ductus arteriosus (odds ratio of 2.50; p=0.04) and a lower chance of presumptive early-onset sepsis (odds ratio of 0.37; p=0.03).

Conclusion: Preterm small-for-gestational-age neonates were associated with peri-intraventricular hemorrhage, retinopathy of prematurity and patent ductus arteriosus. This emphasizes the need of special care for these neonates.

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Conflict of interest statement

Conflict of interest: none.

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References

    1. Kinney MV, Lawn JE, Howson CP, Belizan J. 15 million preterm births annually: what has changed this year? Reprod Health. 2012;9:28. - PMC - PubMed
    1. Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet. 2016; 388(10063):3027-35. Erratum in: Lancet. 2017;389(10082):1884. - PMC - PubMed
    1. Kamali M, Wright JE, Akseer N, Tasic H, Conway K, Brar S, et al. Trends and determinants of newborn mortality in Kyrgyzstan: a countdown country case study. Lancet Glob Health. 2021;9(3):e352-e60. - PMC - PubMed
    1. Inácio QA, Araújo Júnior E, Nardozza LM, Petrini CG, Campos VP, Peixoto AB. Perinatal outcomes of fetuses with early growth restriction, small for gestational age, and adequate for gestational age. Rev Bras Ginecol Obstet. 2019;41(12):688-96. - PMC - PubMed
    1. Liu Q, Yang H, Sun X, Li G. Risk factors and complications of small for gestational age. Pak J Med Sci. 2019;35(5):1199-203. - PMC - PubMed