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Comment
. 2022 May 17;3(5):100642.
doi: 10.1016/j.xcrm.2022.100642.

Too much water drowned the miller: Akkermansia determines immunotherapy responses

Le Li  1 , Florencia McAllister  2
Affiliations
Comment

Too much water drowned the miller: Akkermansia determines immunotherapy responses

Le Li et al. Cell Rep Med. .

Abstract

Derosa et al.1 demonstrated that intestinal Akkermansia muciniphila predicts vigorous response to immunotherapy in non-small-cell lung cancer. Baseline level of this microbe has better value than PD-L1 expression and represents a unique approach for stratifying patients that can benefit from immunotherapy.

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Conflict of interest statement

Declaration of interests F.M. is a scientific advisory board member at Neologics Bio.

Figures

Figure 1
Figure 1
The relative abundance of A. muciniphila stratifies clinical outcomes in NSCLC affected individuals
See this image and copyright information in PMC

Comment on

  • Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer.
    Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B. Derosa L, et al. Nat Med. 2022 Feb;28(2):315-324. doi: 10.1038/s41591-021-01655-5. Epub 2022 Feb 3. Nat Med. 2022. PMID: 35115705 Free PMC article.

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