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Comment
. 2022 May 17;3(5):100643.
doi: 10.1016/j.xcrm.2022.100643.

A topology perspective on macrophages in melanoma metastasis

Alberto Mantovani  1 , Federica Marchesi  2
Affiliations
Comment

A topology perspective on macrophages in melanoma metastasis

Alberto Mantovani et al. Cell Rep Med. .

Abstract

In this issue of Cell Reports Medicine, Martinek et al.1 provide a window into the regional specialization of macrophages infiltrating metastatic melanoma. Combining histo-cytometry and transcriptomics, they identify a signature of stromal macrophages with dendritic cell features and clinical relevance.

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Conflict of interest statement

Declaration of interests A.M. reports personal fees over the last 10 years from Ventana, Pierre Fabre, Verily, AbbVie, Astra Zeneca, Myeloid Therapeutics, Third Rock Venture, Imcheck Therapeutics, Ellipses, Novartis, Roche, Macrophage Pharma, BiovelocIta, Merck, Olatec, Principia; royalties from sale of reagents from Cedarlane Laboratories Ltd, HyCult Biotechnology, eBioscience, BioLegend, Abcam Plc, Novus Biologicals, Enzo Life, and Affymetrix, outside the submitted work. In addition, A.M. is inventor of patents related to cellular and humoral innate immunity.

Figures

Figure 1
Figure 1
Regional specialization of macrophages in melanoma metastasis Two distinct types of macrophages infiltrate melanoma metastasis. iCD14+ macrophages (expressing CD14, TLR4, CD163, and SIGLEC1) are close to tumor and T cells and present intracellular indigested tumor antigens, while sCD14+ macrophages localize in the stroma. A signature of sCD14+ (Cd14-CD2-Ly75) correlates with better survival for melanoma patients. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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