Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 18;12(1):8254.
doi: 10.1038/s41598-022-12040-8.

Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran

Narges Shamsedini  1   2 , Mansooreh Dehghani  3 , Mohammadreza Samaei  4 , Aboolfazl Azhdarpoor  5 , Mohammad Hoseini  5 , Mohammad Fararouei  5 , Shayan Bahrany  1 , Sareh Roosta  6
Affiliations

Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran

Narges Shamsedini et al. Sci Rep. .

Erratum in

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals living near restaurants via a health risk assessment analysis. This cross-sectional study was performed on 57 people living near restaurants and 30 individuals as the control group. Five urinary metabolites of PAHs were monitored. In order to evaluate the effects of the urinary metabolites of PAHs on Malondialdehyde (MDA) concentration, Total Anti-oxidation Capacity (TAC) in urine samples, and C-Reactive Protein (CRP) in serum samples, regression model was used by considering the effects of the possible confounding factors. Non-carcinogenic health risk was calculated, as well. The median concentration of urinary PAHs was 1196.70 and 627.54 ng/g creatinine in the people living near restaurants and the control group, respectively. Among the metabolites, the lowest and highest mean concentrations were related to 9-OHPhe and 1-OHP, respectively in the two study groups. Moreover, PAHs were significantly associated with MDA level and TAC (p < 0.05). Hazard Quotient (HQ) and Hazard Index (HI) were less than 1. Long-term studies are required to determine the actual health effects by identifying the sources of PAHs emission and to find ways to decrease the production of these compounds.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Box plot of creatinine-corrected urinary OH-PAHs in the people living near restaurants and the control group.
Figure 2
Figure 2
The mean concentrations of MDA (µm/mM cr), TAC (mM/mM cr) in urine samples, and CRP (mg/L) in serum samples among (A) individuals living near restaurants and (B) control group participants.
Figure 3
Figure 3
HQs (OHNaps, 2-OHFlu, 9-OHPhe, and 1-OHP) and HIs for (A) people living near restaurants and (B) control group participants.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ambade B, Shankar Sethi S, Basant Giri B, Kumar Biswas J, Bauddh K. Characterization, behavior, and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in the estuary sediments. Bull. Environ. Contam. Toxicol. 2021 doi: 10.1007/s00128-021-03393-3. - DOI - PubMed
    1. Ambade, B., Kumar, A., Latif, M. Emission sources, Characteristics and risk assessment of particulate bound Polycyclic Aromatic Hydrocarbons (PAHs) from traffic sites. Res. Squre (2021). 10.21203/rs.3.rs-328364/v1
    1. Ambade B, Kurwadkar S, Kumar Sankar T, Kumar A. Emission reduction of black carbon and polycyclic aromatic hydrocarbons during COVID-19 pandemic lockdown. Air Qual. Atmos. Health. 2021;14:1081–1095. doi: 10.1007/s11869-021-01004-y. - DOI - PMC - PubMed
    1. Shubhankar B, Ambade B. A review on deposition, distribution of polycyclic aromatic hydrocarbons in different environmental matrix and study its toxicity and carcinogenic effect. Asian J. Chem. 2016;28(11):2341–2345. doi: 10.14233/ajchem.2016.20096. - DOI
    1. Ambade B, ShankarSethi S, Kurwadkarb S, Kumara A, KumarSankar T. Toxicity and health risk assessment of polycyclic aromatic hydrocarbons in surface water, sediments and groundwater vulnerability in Damodar River Basin. Groundw. Sustain. Dev. 2021;136:100553. doi: 10.1016/j.gsd.2021.100553. - DOI

Publication types

Substances