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. 1978 Jul 25;163(3):307-12.
doi: 10.1007/BF00271960.

Induced mutagenesis in dam- mutants of Escherichia coli: a role for 6-methyladenine residues in mutation avoidance

B Glickman, P van den Elsen, M Radman

Induced mutagenesis in dam- mutants of Escherichia coli: a role for 6-methyladenine residues in mutation avoidance

B Glickman et al. Mol Gen Genet. .

Abstract

E. coli strains carrying the dam-3 and dam-4 mutations resulting in reduced levels of 6-methyladenine in the DNA have been found to be more sensitive to base analogue mutagenesis than dam+ strains. Mutagenesis by EMS was also found to be enhanced in dam- strains. Dam- mutants however were not found to be hypermutable by UV light. It is concluded that the dam- strains are deficient in the correct repair of mispairing lesions. The data are consistent with the hypothesis that 6-methyladenine residues in the DNA are involved in strand discrimination during mismatch correction.

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References

    1. J Biol Chem. 1972 Jan 10;247(1):241-8 - PubMed
    1. J Gen Microbiol. 1975 Jun;88(2):259-68 - PubMed
    1. Bacteriol Rev. 1976 Dec;40(4):869-907 - PubMed
    1. Nature. 1976 Sep 23;263(5575):285-9 - PubMed
    1. J Mol Biol. 1977 Jul;114(1):153-68 - PubMed

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