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Case Reports
. 2022 May 13:10:2050313X221094076.
doi: 10.1177/2050313X221094076. eCollection 2022.

Acute interstitial nephritis with Prothionamide

Molla Asnake  1 , Andualem Henock  2 , Menigistu Abayneh  3 , Shimelis Getu  4 , Shewangizaw Hailemariam  5 , Biruk Endalkachew  6 , Dessalegn Zerihun  7
Affiliations
Case Reports

Acute interstitial nephritis with Prothionamide

Molla Asnake et al. SAGE Open Med Case Rep. .

Abstract

Among drug-related complications, drug-related nephrotoxicity is the commonest. It is the cause for 7% of all drug-related toxicities among inpatients and accounts for 20% to 30% of acute renal failure. Acute interstitial nephritis is one of the drug-related adverse reactions and occurs due to a drug-related type 4 hypersensitivity reaction. In this case report, we reported acute interstitial nephritis that causes acute renal failure (acute kidney injury) in a patient taking Prothionamide therapy. This drug-related side effect had not been reported. In this case report, we report a patient who develops fatigability, rash, and intermittent fever after 14 days of taking the drug Prothionamide. The main aims of this case report are to use it as a pharmacovigilance report for drug-producing companies and to consider a further study on this side effect. It is also an alert for clinicians to consider this side effect when patients develop acute interstitial nephritis while taking Prothionamide.

Keywords: Prothionamide; acute interstitial nephritis; drug-induced acute interstitial nephritis.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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