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Comment
. 2022 May;37(5):1120-1121.
doi: 10.1002/mds.29008.

Comment on: Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood

Rana Hanna Al-Shaikh  1 , Karen R Jansen-West  2 , Leonard Petrucelli  2 , Zbigniew K Wszolek  1 , Mercedes Prudencio  2
Affiliations
Comment

Comment on: Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood

Rana Hanna Al-Shaikh et al. Mov Disord. 2022 May.
No abstract available

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Comment in

Comment on

  • Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
    Hübener-Schmid J, Kuhlbrodt K, Peladan J, Faber J, Santana MM, Hengel H, Jacobi H, Reetz K, Garcia-Moreno H, Raposo M, van Gaalen J, Infante J, Steiner KM, de Vries J, Verbeek MM, Giunti P, Pereira de Almeida L, Lima M, van de Warrenburg B, Schöls L, Klockgether T, Synofzik M; European Spinocerebellar Ataxia Type-3/Machado-Joseph Disease Initiative (ESMI) Study Group; Riess O. Hübener-Schmid J, et al. Mov Disord. 2021 Nov;36(11):2675-2681. doi: 10.1002/mds.28749. Epub 2021 Aug 16. Mov Disord. 2021. PMID: 34397117

References

    1. Hübener-Schmid J, Kuhlbrodt K, Peladan J, et al. Polyglutamine-expanded Ataxin-3: a target engagement marker for spinocerebellar ataxia type 3 in peripheral blood. Mov Disord 2021;36(11):2675-2681.
    1. Prudencio M, Garcia-Moreno H, Jansen-West KR, et al. Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3. Sci Transl Med 2020;12(566):eabb7086.
    1. Koike Y, Jansen-West KR, Hanna Al-Shaikh R, et al. Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. Parkinsonism Relat Disord 2021;89:151-154.
    1. Hwang J, Banerjee M, Venable AS, et al. Quantitation of low abundant soluble biomarkers using high sensitivity single molecule counting technology. Methods 2019;158:69-76.

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