Sex-different changes of body composition in aging: a systemic review

Abstract

Objective: Aging causes changes in body composition, in which differences in the distribution and amount of fat and muscle tissue affect the development of various diseases according to sex. We conducted a systemic review of the literature and examined the relationship between body composition differences and related health conditions or diseases in older men and women.

Methods: Three different electronic databases (MEDLINE, Web of Science, and Embase) were used to find articles from 2000 until March 2022. Information on the study design characteristics, setting, measure of body composition, and health outcomes was extracted.

Results: A total of 217 articles were retrieved, and 28 studies met the inclusion criteria. The included studies showed that older men have larger skeletal muscle mass (sMM) than women, while older women have larger fat mass (FM) than men. sMM has a favorable effect on physical performance, bone density, metabolism, cognitive function, and mortality in both men and women; however, the effects of sMM in women are less significant and even negligible compared to those in men. FM is significantly unfavorable for physical performance in women but sometimes favorable or unfavorable for glucose level and cognitive and lung function according to location. FM in men is usually less important for function, bone density, glucose level, and cognitive function than in women.

Conclusion: Changes in muscle and fat distribution according to aging and their correlation with health outcomes differ according to sex. Muscle mass may not always be favorable, and fat mass may not always be unfavorable in older adults.

Keywords: aging; fat; muscle; older adults.