Different methods, techniques and their limitations in protein structure prediction: A review

Abstract

Because of the increase in different types of diseases in human habitats, demands for designing various types of drugs are also increasing. Protein and its structure play a very important role in drug design. Therefore researchers from different areas like mathematics, medicines, and computer science are teaming up for getting better solutions in the said field. In this paper, we have discussed different methods of secondary and tertiary protein structure prediction (PSP), along with the limitations of different approaches. Different types of datasets used in PSP are also discussed here. This paper also tells about different performance measures to evaluate the prediction accuracy of PSP methods. Different software's/servers are available for download, which are used to find the protein structures for the input protein sequence. These softwares will also help to compare the performance of any new algorithm with other available methods. Details of those softwares are also mentioned in this paper.

Keywords: Conformational sampling; Protein secondary structure prediction; Protein tertiary structure prediction.