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Review
. 2022 Jun;76(6):1318-1329.
doi: 10.1016/j.jhep.2022.03.003.

"Beyond MELD" - Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation

Jin Ge  1 , W Ray Kim  2 , Jennifer C Lai  1 , Allison J Kwong  3
Affiliations
Review

"Beyond MELD" - Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation

Jin Ge et al. J Hepatol. 2022 Jun.

Abstract

In this review article, we discuss the model for end-stage liver disease (MELD) score and its dual purpose in general and transplant hepatology. As the landscape of liver disease and transplantation has evolved considerably since the advent of the MELD score, we summarise emerging concepts, methodologies, and technologies that may improve mortality prognostication in the future. Finally, we explore how these novel concepts and technologies may be incorporated into clinical practice.

Keywords: Allocation; Clinical Decision Support; EHR; Frailty; MELD; OMOP; Prognostication; Sarcopenia.

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Conflict of interest statement

Conflict of interest The authors of this manuscript have no conflicts of interest to disclose as described by the Journal of Hepatology. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1.
Fig. 1.. Rapid-cycle testing in ‘electronic’ randomised controlled trials.
Schematic of rapid-cycle ‘electronic’ randomised controlled trials could be implemented using CDS systems: computational risk assessment allows a patient to be randomised for an intervention associated with a CDS, the results of which could then be used to iteratively modify the risk stratification algorithm or the CDS system. CDS, clinical decision support.
See this image and copyright information in PMC

Comment in

References

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