doi: 10.1038/274775a0.
Molecular basis of base substitution hotspots in Escherichia coli
- PMID: 355893
- DOI: 10.1038/274775a0
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Molecular basis of base substitution hotspots in Escherichia coli
Nature.
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Abstract
In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.
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