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. 1978 Aug 24;274(5673):775-80.
doi: 10.1038/274775a0.

Molecular basis of base substitution hotspots in Escherichia coli

C Coulondre, J H Miller, P J Farabaugh, W Gilbert

Molecular basis of base substitution hotspots in Escherichia coli

C Coulondre et al. Nature. .

Abstract

In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.

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