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Comment
. 2022 Oct;117(10):2750-2751.
doi: 10.1111/add.15947. Epub 2022 May 31.

Naloxone administration-no balance without titration

Arne Kristian Skulberg  1   2 , Ida Tylleskär  1   3 , Ola Dale  1
Affiliations
Comment

Naloxone administration-no balance without titration

Arne Kristian Skulberg et al. Addiction. 2022 Oct.
No abstract available

Keywords: Fentanyl; administration; intramuscular; intranasal; naloxone; opiate overdose.

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References

REFERENCES

    1. Jauncey M, Bartlett M, Roxburgh A. Commentary on Skulberg et al.: Naloxone administration-finding the balance. Addiction. 2022;117:1668-9.
    1. Skulberg AK, Tylleskär I, Valberg M, Braarud AC, Dale J, Heyerdahl F, et al. Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomized, controlled trial. Addiction. 2022;117:1658-67.
    1. Burns G, DeRienz RT, Baker DD, Casavant M, Spiller HA. Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse? Clin Toxicol. 2016;54:420-3.
    1. Torralva R, Janowsky A. Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis. J Pharmacol Exp Ther. 2019;371:453-75.
    1. Miner NB, Schutzer WE, Zarnegarnia Y, Janowsky A, Torralva R. Fentanyl causes naloxone-resistant vocal cord closure: a platform for testing opioid overdose treatments. Drug Alcohol Depend. 2021;227:108974.

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