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Meta-Analysis
. 2022 Jul;6(7):1014-1026.
doi: 10.1038/s41562-022-01343-5. Epub 2022 May 19.

Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

Soyeon Kim #  1   2   3   4 , Kiwon Kim #  5 , Mi Yeong Hwang #  6 , Hyunwoong Ko  7 , Sang-Hyuk Jung  1 , Injeong Shim  1 , Soojin Cha  1 , Hyewon Lee  8 , Beomsu Kim  1 , Joohyun Yoon  2 , Tae Hyon Ha  2 , Doh Kwan Kim  9 , Jinho Kim  10 , Woong-Yang Park  11 , Aysu Okbay  12 , Bong-Jo Kim  6 , Young Jin Kim  13 , Woojae Myung  14 , Hong-Hee Won  15   16
Affiliations
Meta-Analysis

Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

Soyeon Kim et al. Nat Hum Behav. 2022 Jul.

Abstract

Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.

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