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. 2022 Oct;31(10):3077-3085.
doi: 10.1007/s11136-022-03157-4. Epub 2022 May 19.

Utility values and its time to deterioration in breast cancer patients after diagnosis and during treatments

Rana El Haidari  1 , Amelie Anota  2   3 , Tienhan S Dabakuyo-Yonli  3   4 , Francis Guillemin  3   5 , Thierry Conroy  6   7 , Michel Velten  3   8   9 , Damien Jolly  3   10 , Sylvain Causeret  11 , Jean Cuisenier  11 , Olivier Graesslin  12 , Linda Abou Abbas  13 , Virginie Nerich  2   14
Affiliations

Utility values and its time to deterioration in breast cancer patients after diagnosis and during treatments

Rana El Haidari et al. Qual Life Res. 2022 Oct.

Abstract

Background: The potential effects of breast cancer (BC) on health-related quality of life (HRQoL) should be considered in clinical and policy decision-making, as the economic burden of BC management is currently assessed. In the last decades, time-to-HRQoL score deterioration (TTD) has been proposed as an approach to the analysis of longitudinal HRQoL in oncology. The main objectives of the current study were to investigate the evolution of the utility values in BC patients after diagnosis and during follow-ups and to evaluate the TTD in utility values among women in all stages of BC.

Methods: Health-state utility values (HSUV) were assessed using the EuroQol 5-Dimension 3-Level at diagnosis, at the end of the first hospitalization and 3 and 6 months after the first hospitalization. For a given baseline score, HSUV was considered to have deteriorated if this score decreased by ≥ 0.08 points of the EQ-5D utility index score and ≥ 7 points of the EQ visual analogue scale. TTD curves were calculated using the Kaplan-Meier estimation method.

Results: Overall 381 patients were enrolled between February 2006 and February 2008. The highest proportions of respondents at the baseline and all follow-ups reporting some and extreme problems were in pain discomfort and anxiety/depression dimensions; more than 80% of patients experienced a deterioration in EQ-5D utility index score and EQ VAS score with a median TTD of 3.15 months and 6.24 Months, respectively.

Conclusions: BC patients undergoing therapy need psychological support to cope with their discomfort, pain, depression, anxiety, and fear during the process of diagnosis and treatment to improve their QoL.

Keywords: Breast cancer; Health-state utility values; Time to deterioration.

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