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Comment
. 2021 Jun 11;2(6):637-639.
doi: 10.1016/j.medj.2021.05.005. Epub 2021 Jun 15.

Acetylated tau: A missing link between head injury and dementia

Zhen Zhao  1 , Berislav V Zlokovic  2
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Free article
Comment

Acetylated tau: A missing link between head injury and dementia

Zhen Zhao et al. Med. .
Free article

Abstract

Head injury is the most significant environmental risk factor for Alzheimer's disease and dementia. Yet, our understanding of its pathophysiology remains limited, and therapeutic targets remain elusive. In a recent issue of Cell, Shin et al. discovered a promising molecular pathway linking head injury to Alzheimer's disease.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Reducing acetylated tau is neuroprotective in brain injury.
    Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF, Seth D, Allen RS, Motz CT, Rao SR, Skelton LA, Pardue MT, Fliesler SJ, Wang C, Tracy TE, Gan L, Liebl DJ, Savarraj JPJ, Torres GL, Ahnstedt H, McCullough LD, Kitagawa RS, Choi HA, Zhang P, Hou Y, Chiang CW, Li L, Ortiz F, Kilgore JA, Williams NS, Whitehair VC, Gefen T, Flanagan ME, Stamler JS, Jain MK, Kraus A, Cheng F, Reynolds JD, Pieper AA. Shin MK, et al. Cell. 2021 May 13;184(10):2715-2732.e23. doi: 10.1016/j.cell.2021.03.032. Epub 2021 Apr 13. Cell. 2021. PMID: 33852912 Free PMC article.

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