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doi: 10.1016/j.medj.2021.12.006.
Harnessing defective viruses to fight infections
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- PMID: 35590140
- DOI: 10.1016/j.medj.2021.12.006
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Harnessing defective viruses to fight infections
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Abstract
One of the most pressing challenges in medicine is to develop fast and effective strategies to combat infections. Xiao et al.1 report proof-of-concept experiments for the use of defective viral genomes as broad-spectrum antivirals by harnessing their ability to stimulate the innate immune response.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests C.B.L. has a related patent: Methods and Compositions for Stimulating Immune Response Using Potent Immunostimulatory RNA Motifs, patent number 10,624,964, granted on April 21, 2020. The priority date for the patent is May 1, 2015.
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A defective viral genome strategy elicits broad protective immunity against respiratory viruses.Cell. 2021 Dec 9;184(25):6037-6051.e14. doi: 10.1016/j.cell.2021.11.023. Epub 2021 Nov 18. Cell. 2021. PMID: 34852237 Free PMC article.
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