Durability of immune responses to the BNT162b2 mRNA vaccine

Mehul S Suthar¹, Prabhu S Arunachalam², Mengyun Hu², Noah Reis², Meera Trisal², Olivia Raeber³, Sharon Chinthrajah³, Meredith E Davis-Gardner⁴, Kelly Manning⁴, Prakriti Mudvari⁵, Eli Boritz⁵, Sucheta Godbole⁵, Amy R Henry⁵, Daniel C Douek⁵, Peter Halfmann⁶, Yoshihiro Kawaoka⁷, Scott D Boyd⁸, Mark M Davis⁹, Veronika I Zarnitsyna¹⁰, Kari Nadeau¹¹, Bali Pulendran¹²

Affiliations

¹ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: msuthar@emory.edu.
² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
³ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA.
⁴ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
⁵ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
⁶ University of Wisconsin, Madison, WI, USA.
⁷ University of Wisconsin, Madison, WI, USA; National Center for Global Health and Medicine, Tokyo, Japan; University of Tokyo, Tokyo, Japan.
⁸ Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
⁹ Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
¹⁰ Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
¹¹ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA; Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
¹² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: bpulend@stanford.edu.

PMID: 35590141
PMCID: PMC9304003
DOI: 10.1016/j.medj.2021.12.005

Durability of immune responses to the BNT162b2 mRNA vaccine

Mehul S Suthar et al. Med. 2022.

. 2022 Jan 14;3(1):25-27.

doi: 10.1016/j.medj.2021.12.005.

Authors

Affiliations

¹ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: msuthar@emory.edu.
² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
³ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA.
⁴ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
⁵ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
⁶ University of Wisconsin, Madison, WI, USA.
⁷ University of Wisconsin, Madison, WI, USA; National Center for Global Health and Medicine, Tokyo, Japan; University of Tokyo, Tokyo, Japan.
⁸ Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
⁹ Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
¹⁰ Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
¹¹ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA; Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
¹² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: bpulend@stanford.edu.

PMID: 35590141
PMCID: PMC9304003
DOI: 10.1016/j.medj.2021.12.005

Abstract

Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.

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Conflict of interest statement

Declaration of interests B.P. serves on the External Immunology Network of GSK and on the Scientific Advisory Board of Sanofi and Medicago. M.S. serves on the advisory board for Moderna.

References

1. Goldberg Y et al. Waning Immunity after the BNT162b2 Vaccine in Israel. N Engl J Med, doi: 10.1056/NEJMoa2114228 (2021). - DOI - PMC - PubMed
1. Pegu A et al. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science, doi: 10.1126/science.abj4176 (2021). - DOI - PMC - PubMed
1. Levin EG et al. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months. N Engl J Med, doi: 10.1056/NEJMoa2114583 (2021). - DOI - PMC - PubMed
1. Goel RR et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern. bioRxiv, doi: 10.1101/2021.08.23.457229 (2021). - DOI
1. Arunachalam PS et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature, doi: 10.1038/s41586-021-03791-x (2021). - DOI - PMC - PubMed

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Durability of immune responses to the BNT162b2 mRNA vaccine

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Durability of immune responses to the BNT162b2 mRNA vaccine

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Conflict of interest statement

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