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Comment
. 2021 Dec 10;2(12):1289-1291.
doi: 10.1016/j.medj.2021.11.002.

PfSPZ Vaccine learns a lesson

Irfan Zaidi  1 , Patrick E Duffy  2
Affiliations
Comment

PfSPZ Vaccine learns a lesson

Irfan Zaidi et al. Med. .

Abstract

In Kenya, the first trial of the attenuated whole organism PfSPZ Vaccine in infants has shown little efficacy against malaria infection, whereas trials in African adults have repeatedly observed protection. Differences in immune responses offer clues to the possible reasons.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest associated with this manuscript.

Figures

Figure 1.
Figure 1.
Differences in PfSPZ Vaccine immune responses and efficacy in Malian adults versus Kenyan infants who received three doses of 1.8 × 106 PfSPZ.
See this image and copyright information in PMC

Comment on

References

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