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Comment
. 2022 Apr 8;3(4):217-219.
doi: 10.1016/j.medj.2022.03.003.

Does HIV-1 virulence matter in the ART era?

Eric Lewitus  1 , Morgane Rolland  2
Affiliations
Free article
Comment

Does HIV-1 virulence matter in the ART era?

Eric Lewitus et al. Med. .
Free article

Abstract

Are highly virulent HIV-1 strains circulating? Wymant et al.1 described the first concrete example of a virulent HIV-1 strain associated with high viremia and fast CD4 T cell decline. This is certainly not an isolated case, emphasizing the need for thorough HIV-1 surveillance and universal access to treatment.

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Conflict of interest statement

Declaration of Interest The views expressed are those of the authors and should not be construed to represent the positions of the US Army, the Department of Defense, the Department of Health and Human Services, or the Henry M. Jackson Foundation for the Advancement of Military Medicine. The authors declare no competing financial interests.

Comment on

  • A highly virulent variant of HIV-1 circulating in the Netherlands.
    Wymant C, Bezemer D, Blanquart F, Ferretti L, Gall A, Hall M, Golubchik T, Bakker M, Ong SH, Zhao L, Bonsall D, de Cesare M, MacIntyre-Cockett G, Abeler-Dörner L, Albert J, Bannert N, Fellay J, Grabowski MK, Gunsenheimer-Bartmeyer B, Günthard HF, Kivelä P, Kouyos RD, Laeyendecker O, Meyer L, Porter K, Ristola M, van Sighem A, Berkhout B, Kellam P, Cornelissen M, Reiss P, Fraser C; Netherlands ATHENA HIV Observational Cohort†; BEEHIVE Collaboration†. Wymant C, et al. Science. 2022 Feb 4;375(6580):540-545. doi: 10.1126/science.abk1688. Epub 2022 Feb 3. Science. 2022. PMID: 35113714

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