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Comment
. 2022 Apr 8;3(4):223-225.
doi: 10.1016/j.medj.2022.03.006.

Unveiling the mechanisms of hematopoietic stem cell transplantation: Balancing cell senescence and proliferation in cancer and beyond

Molly Monsour  1 , Cesario V Borlongan  2
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Comment

Unveiling the mechanisms of hematopoietic stem cell transplantation: Balancing cell senescence and proliferation in cancer and beyond

Molly Monsour et al. Med. .

Abstract

In a recent Nature Medicine publication, Sailor et al.1 elucidate the complex mechanism of hematopoietic stem cell transplantation (HSCT) and chemotherapy, highlighting the occurrence of host microglia senescence coupled with donor macrophage engraftment. These findings warrant a more in-depth understanding of HSCT and its adjunctive therapies to enhance current and future treatments for cancer and a plethora of pro-inflammatory disorders.

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Conflict of interest statement

Declaration of interests C.V.B. was funded by the National Institutes of Health (NIH) R01NS090962, NIH R01NS102395, and NIH R21NS109575. Additionally, C.V.B. was funded and received royalties and stock options from Astellas, Asterias, Sanbio, Athersys, KMPHC, and International Stem Cell Corporation and has also received consultant compensation from Chiesi Farmaceutici. C.V.B. also declares patents and patent applications related to stem cell therapy.

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