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Comment
. 2022 Mar 11;3(3):155-156.
doi: 10.1016/j.medj.2022.02.003.

Primed for toxicity: CD4+ T cells and immune checkpoint inhibitors

Douglas B Johnson  1 , Justin M Balko  2
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Comment

Primed for toxicity: CD4+ T cells and immune checkpoint inhibitors

Douglas B Johnson et al. Med. .
Free article

Abstract

Immune-related adverse events (irAEs) occur in almost every organ system in a seemingly unpredictable fashion, causing substantial morbidity and mortality. Lozano et al.1 report peripheral blood profiling from patients receiving immune checkpoint inhibitors, identifying that diverse CD4+ effector memory T cells present prior to treatment are associated with severe irAEs.

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Conflict of interest statement

Declaration of interests D.B.J. has served on advisory boards or as a consultant for BMS, Catalyst Biopharma, Iovance, Jansen, Mallinckrodt, Merck, Mosaic ImmunoEngineering, Novartis, Oncosec, Pfizer, and Targovax and has received research funding from BMS and Incyte. J.M.B. receives research support from Genentech/Roche and Incyte Corporation and is an inventor on provisional patents regarding immunotherapy targets and biomarkers in cancer.

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