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Comment
. 2021 Nov 12;2(11):1198-1200.
doi: 10.1016/j.medj.2021.10.007.

Sterile protection against malaria in humans with a monoclonal antibody

Carlota Dobaño  1 , Gemma Moncunill  2
Affiliations
Free article
Comment

Sterile protection against malaria in humans with a monoclonal antibody

Carlota Dobaño et al. Med. .
Free article

Abstract

The long time that it is taking to achieve a fully efficacious malaria vaccine calls for developing additional control strategies. A recent paper led by the Seder group provides proof of concept that passive administration of monoclonal antibodies can prevent Plasmodium falciparum parasitemia after controlled infection in malaria-naive adults.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • A Monoclonal Antibody for Malaria Prevention.
    Gaudinski MR, Berkowitz NM, Idris AH, Coates EE, Holman LA, Mendoza F, Gordon IJ, Plummer SH, Trofymenko O, Hu Z, Campos Chagas A, O'Connell S, Basappa M, Douek N, Narpala SR, Barry CR, Widge AT, Hicks R, Awan SF, Wu RL, Hickman S, Wycuff D, Stein JA, Case C, Evans BP, Carlton K, Gall JG, Vazquez S, Flach B, Chen GL, Francica JR, Flynn BJ, Kisalu NK, Capparelli EV, McDermott A, Mascola JR, Ledgerwood JE, Seder RA; VRC 612 Study Team. Gaudinski MR, et al. N Engl J Med. 2021 Aug 26;385(9):803-814. doi: 10.1056/NEJMoa2034031. Epub 2021 Aug 11. N Engl J Med. 2021. PMID: 34379916 Free PMC article. Clinical Trial.

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