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Comment
. 2021 Oct 8;2(10):1114-1116.
doi: 10.1016/j.medj.2021.09.005.

Lightning does strike twice: leveraging phased variants to enhance minimal residual disease detection

Alexandre P Cheng  1 , Dan A Landau  2
Affiliations
Free article
Comment

Lightning does strike twice: leveraging phased variants to enhance minimal residual disease detection

Alexandre P Cheng et al. Med. .
Free article

Abstract

Liquid biopsy detection of residual cancer after therapy offers to transform oncology care. Nonetheless, in the residual cancer context, signals are sparse and are hindered by technical sequencing noise. Kurtz et al.1 introduce phased variant enrichment and detection sequencing (phasED-seq) to increase the circulating tumor DNA signal-to-noise ratio and detect minimal residual disease with unprecedented sensitivity.

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Conflict of interest statement

Declaration of interest D.L. is a co-founder of C2i Genomics and a member of its scientific advisory board.

Comment on

  • Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA.
    Kurtz DM, Soo J, Co Ting Keh L, Alig S, Chabon JJ, Sworder BJ, Schultz A, Jin MC, Scherer F, Garofalo A, Macaulay CW, Hamilton EG, Chen B, Olsen M, Schroers-Martin JG, Craig AFM, Moding EJ, Esfahani MS, Liu CL, Dührsen U, Hüttmann A, Casasnovas RO, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Kurtz DM, et al. Nat Biotechnol. 2021 Dec;39(12):1537-1547. doi: 10.1038/s41587-021-00981-w. Epub 2021 Jul 22. Nat Biotechnol. 2021. PMID: 34294911 Free PMC article.

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