Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Feb 11;3(2):90-92.
doi: 10.1016/j.medj.2022.01.010.

Cell-free plasma RNA signatures as a surrogate biomarker of pregnancy health

Yalda Afshar  1 , S Ananth Karumanchi  2
Affiliations
Free article
Comment

Cell-free plasma RNA signatures as a surrogate biomarker of pregnancy health

Yalda Afshar et al. Med. .
Free article

Abstract

Molecular diagnostics based on sequencing of plasma cell-free DNA has transformed obstetric care by accurately diagnosing fetal aneuploidy in early pregnancy. Rasmussen et al. now report plasma cell-free RNA profiling that could transform obstetrics by providing comprehensive molecular monitoring of pregnancy progression for both healthy and complicated pregnancies such as preeclampsia.1.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests S.A.K. is a co-inventor on angiogenic biomarker patents in the field of preeclampsia held by Harvard Hospitals. S.A.K. has financial interest in Aggamin Therapeutics. In addition, S.A.K. has received research grants from Thermofisher and Siemens and has served as a consultant to Thermofisher and Roche. Y.A. discloses no conflicts.

Comment on

  • RNA profiles reveal signatures of future health and disease in pregnancy.
    Rasmussen M, Reddy M, Nolan R, Camunas-Soler J, Khodursky A, Scheller NM, Cantonwine DE, Engelbrechtsen L, Mi JD, Dutta A, Brundage T, Siddiqui F, Thao M, Gee EPS, La J, Baruch-Gravett C, Santillan MK, Deb S, Ame SM, Ali SM, Adkins M, DePristo MA, Lee M, Namsaraev E, Gybel-Brask DJ, Skibsted L, Litch JA, Santillan DA, Sazawal S, Tribe RM, Roberts JM, Jain M, Høgdall E, Holzman C, Quake SR, Elovitz MA, McElrath TF. Rasmussen M, et al. Nature. 2022 Jan;601(7893):422-427. doi: 10.1038/s41586-021-04249-w. Epub 2022 Jan 5. Nature. 2022. PMID: 34987224 Free PMC article.

LinkOut - more resources