Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework
- PMID: 35591794
- PMCID: PMC9541235
- DOI: 10.1111/resp.14294
Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework
Keywords: airway markers; asthma; eosinophils; inflammation; nitric oxide.
Conflict of interest statement
Simon Couillard received non‐restricted research grants from Sanofi‐Genzyme, the Quebec Respiratory Health Research Network and the Association Pulmonaire du Québec, outside the submitted work; received speaker honoraria from GlaxoSmithKline, Sanofi‐Regeneron and AstraZeneca, outside the submitted work; and is on the advisory board of Biometry Inc, outside the submitted work. In the last 5 years, Ian D. Pavord has received speaker's honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Aerocrine AB, Almirall, Novartis, Teva, Chiesi, Sanofi/Regeneron, Menarini and GSK, and payments for organizing educational events from AstraZeneca, GSK, Sanofi/Regeneron and Teva. He has received honoraria for attending advisory panels with Genentech, Sanofi/Regeneron, AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Teva, Merck, Circassia, Chiesi and Knopp, and payments to support FDA approval meetings from GSK. He has received sponsorship to attend international scientific meetings from Boehringer Ingelheim, GSK, AstraZeneca, Teva and Chiesi. He has received grants from Chiesi and Sanofi Genzyme. He is co‐patent holder of the rights to the Leicester Cough Questionnaire and has received payments for its use in clinical trials from Merck, Bayer and Insmed. During 2014–2015, he was an expert witness for a patent dispute involving AstraZeneca and Teva. Liam G. Heaney has received grant funding, participated in advisory boards and given lectures at meetings supported by Amgen, AstraZeneca, Boehringer Ingelheim, Circassia, Hoffmann la Roche, GlaxoSmithKline, Novartis, Theravance, Evelo Biosciences, Sanofi and Teva. He has received grants from MedImmune, Novartis UK, Roche/Genentech Inc, Glaxo Smith Kline, Amgen, Genentech/Hoffman la Roche, Astra Zeneca, MedImmune, Glaxo Smith Kline, Aerocrine and Vitalograph. He has received sponsorship for attending international scientific meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK and Napp Pharmaceuticals. He has also taken part in asthma clinical trials sponsored by AstraZeneca, Boehringer Ingelheim, Hoffmann la Roche and GlaxoSmithKline for which his institution received remuneration. He is the Academic Lead for the Medical Research Council Stratified Medicine UK Consortium in Severe Asthma which involves industrial partnerships with a number of pharmaceutical companies including Amgen, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Hoffmann la Roche and Janssen. Nayia Petousi is supported from the NIHR Oxford BRC. She has received grants from the University of Oxford and NIHR research capability funding from Oxford University Hospitals outside the submitted work. She has received personal fees from Astra Zeneca, outside the submitted work. Timothy S. C. Hinks has received grants from the Wellcome Trust, The Guardians of the Beit Fellowship, Pfizer Inc., Kymab Ltd, Sensyne Health, University of Oxford and from the NIHR Oxford BRC, outside the submitted work. He has received personal fees from Astra Zeneca, TEVA, Omniprex and Peer Voice, outside the submitted work.
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