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Review
. 2022;75(1):28-34.
doi: 10.5173/ceju.2022.0292. Epub 2022 Jan 13.

Can we lower the rates of cystectomy complications by modifying risk factors? A review of the literature

Taras Hladun  1 , Jakub Ratajczak  1 , Maciej Salagierski  2
Affiliations
Review

Can we lower the rates of cystectomy complications by modifying risk factors? A review of the literature

Taras Hladun et al. Cent European J Urol. 2022.

Abstract

Introduction: Radical cystectomy (RC), beyond its therapeutic effect, is associated with significant rates of complications, hospital readmissions and mortality. In recent years much research has been made in order to clarify the main reasons of these events. This article, based on a literature review, presents the impact of risk factors on RC complications and highlights possible modifications of these factors to reach better RC outcome.

Material and methods: PubMed, Science Direct, Google Scholar databases were searched using key-words to identify studies about risk factors and RC complications between 2010 and 2021. A total of 96 articles were retrieved and studied as full-text versions. The most significant data was targeted, analysed and categorized according to the article's design.

Results: All the most valuable risk factors of RC complications were grouped in patient-related, treatment-related risk factors and subgrouped in nonmodifiable, modifiable and potentially modifiable categories. All the modifiable and potentially modifiable risk factors were found to have considerable value, as their adjustment lowers the rates of morbidity and mortality.

Conclusions: Proper identification and adjustment of the risk factors present the possibility of better RC results. Although, in advanced disease and highly morbid cases, complications are not fully omit-table. Management of bladder cancer (BC) in high-volume centres using new technologies offers lower rates of complications. To sum up, rigorous interdisciplinary presurgical patient preparation should be implemented in BC management.

Keywords: bladder cancer; complications; radical cystectomy; risk factors.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Risk factors of radical cystectomy complications.
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References

    1. Witjes JA, Bruins HM, Cathomas R, et al. Guidelines on Muscle-invasive and Metastatic Bladder Cancer. EAU Guidelines. Edn; presented at the EAU Annual Congress Milan 2021; Arnhem, The Netherlands: EAU Guidelines Office; ISBN 978-94-92671-13-4.
    1. Krajewski W, Zdrojowy R, Tupikowski K, Małkiewicz B, Kołodziej A. How to lower postoperative complications after radical cystectomy - a review. Cent European J Urol. 2016;69:370–376. - PMC - PubMed
    1. Lavallée LT, Schramm D, Witiuk K, et al. Peri-operative morbidity associated with radical cystectomy in a multicenter database of community and academic hospitals. PLoS One. 2014;9:e111281. - PMC - PubMed
    1. Jun IJ, Kim J, Kim HG, Koh GH, Hwang JH, Kim YK. Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction. Sci Rep. 2019;9:14096. - PMC - PubMed
    1. Kim S, Kokorovic A, Sharma V, et al. Factors predicting early mortality after radical cystectomy for urothelial carcinoma in a contemporary cohort of patients. Can Urol Assoc J. 2020;14:E636–E642. - PMC - PubMed

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