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Review
. 2022 Jul;26(1):227.
doi: 10.3892/mmr.2022.12743. Epub 2022 May 20.

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)

Jicheng Wang  1 , Tengyun Wang  1 , Fujie Zhang  1 , Yangyang Zhang  1 , Yongzhi Guo  1 , Xin Jiang  1 , Bo Yang  1
Affiliations
Review

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)

Jicheng Wang et al. Mol Med Rep. 2022 Jul.

Abstract

Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are therefore defined as pluripotent cells. BMSCs have become extremely important seed cells in gene therapy, tissue engineering, cell replacement therapy and regenerative medicine due to their potential in multilineage differentiation, self‑renewal, immune regulation and other fields. Circular RNAs (circRNAs) are a class of non‑coding RNAs that are widely present in eukaryotic cells. Unlike standard linear RNAs, circRNAs form covalently closed continuous loops with no 5' or 3' polarity. circRNAs are abundantly expressed in cells and tissues, and are highly conserved and relatively stable during evolution. Numerous studies have shown that circRNAs play an important role in the osteogenic differentiation of BMSCs. Further studies on the role of circRNAs in the osteogenic differentiation of BMSCs can provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.

Keywords: BMSC; bone defects; circRNA; osteogenic differentiation; treatment.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Schematic illustration of the biogenesis of circRNAs. pre-mRNA, pre-messenger RNA; RBP, RNA-binding protein; circRNA, circular RNA; QKI, protein quaking; MBL, muscleblind protein.
See this image and copyright information in PMC

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