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Review
. 2022 May 25;54(5):593-603.
doi: 10.3724/abbs.2022029.

Gene, virulence and related regulatory mechanisms in Cryptococcus gattii

Yemei Huang  1 , Xuelei Zang  2 , Chen Yang  2 , Hengyu Deng  3 , Xidong Ma  2 , Mei Xie  2 , Meng Zhou  4 , Jialin Song  3 , Xinying Xue  1   2   3
Affiliations
Review

Gene, virulence and related regulatory mechanisms in Cryptococcus gattii

Yemei Huang et al. Acta Biochim Biophys Sin (Shanghai). .

Abstract

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms.

Keywords: genotype; regulation mechanism; virulence.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

None
Figure1
Traditional virulence factors and some potential novel virulence factors These factors include capsule, melanin, chitin, chitosan, the ability to grow at physiological temperature, extracellular enzymes, extracellular vesicles, heat-shock protein, core-degrading enzymes, biofilms, the phagosomal F-actin structure, and extracellular fibrils.
See this image and copyright information in PMC

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