Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

doi:10.1111/cen.14757

Review

. 2022 Aug;97(2):165-173.

doi: 10.1111/cen.14757. Epub 2022 May 30.

Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

Anju E Joham^{1

2}, Terhi Piltonen³, Marla E Lujan⁴, Sylvia Kiconco¹, Chau Thien Tay^{1

2}

Affiliations

¹ Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
² Department of Diabetes and Vascular Medicine, Monash Health, Melbourne, Victoria, Australia.
³ Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
⁴ Division of Nutritional Sciences, Colleges of Human Ecology and Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA.

PMID: 35593530
PMCID: PMC9541175
DOI: 10.1111/cen.14757

Review

Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

Anju E Joham et al. Clin Endocrinol (Oxf). 2022 Aug.

. 2022 Aug;97(2):165-173.

doi: 10.1111/cen.14757. Epub 2022 May 30.

Authors

Anju E Joham^{1

2}, Terhi Piltonen³, Marla E Lujan⁴, Sylvia Kiconco¹, Chau Thien Tay^{1

2}

Affiliations

¹ Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
² Department of Diabetes and Vascular Medicine, Monash Health, Melbourne, Victoria, Australia.
³ Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
⁴ Division of Nutritional Sciences, Colleges of Human Ecology and Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA.

PMID: 35593530
PMCID: PMC9541175
DOI: 10.1111/cen.14757

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8%-13% of reproductive-aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic-ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. In this review, we will discuss challenges in the diagnosis of PCOS and understanding of the natural history of PCOS.

Keywords: challenges; diagnosis; natural history; phenotypes; polycystic ovary syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta‐analysis. Hum Reprod. 2016;31:2841‐2855. - PubMed
1. Naz MSG, Tehrani FR, Majd HA, et al. The prevalence of polycystic ovary syndrome in adolescents: a systematic review and meta‐analysis. Int J Reprod Biomed. 2019;17:533‐542. - PMC - PubMed
1. Rotterdam ESHRE/ASRM‐Sponsored PCOS Consensus Workshop Group . Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41‐47. - PubMed
1. Kakoly NS, Earnest A, Teede HJ, Moran LJ, Joham AE. The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome. Diabetes Care. 2019;42:560‐567. - PubMed
1. Joham A, Teede H, Ranasinha S, Zoungas S, Boyle J. Infertility and assisted reproductive technology use in women with polycystic ovary syndrome: data from the Australian longitudinal women's health study. J Women's Health. 2015;24:299‐307. - PubMed

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[1] Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta‐analysis. Hum Reprod. 2016;31:2841‐2855. - PubMed

[2] Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta‐analysis. Hum Reprod. 2016;31:2841‐2855. - PubMed

[3] Naz MSG, Tehrani FR, Majd HA, et al. The prevalence of polycystic ovary syndrome in adolescents: a systematic review and meta‐analysis. Int J Reprod Biomed. 2019;17:533‐542. - PMC - PubMed

[4] Naz MSG, Tehrani FR, Majd HA, et al. The prevalence of polycystic ovary syndrome in adolescents: a systematic review and meta‐analysis. Int J Reprod Biomed. 2019;17:533‐542. - PMC - PubMed

[5] Rotterdam ESHRE/ASRM‐Sponsored PCOS Consensus Workshop Group . Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41‐47. - PubMed

[6] Rotterdam ESHRE/ASRM‐Sponsored PCOS Consensus Workshop Group . Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41‐47. - PubMed

[7] Kakoly NS, Earnest A, Teede HJ, Moran LJ, Joham AE. The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome. Diabetes Care. 2019;42:560‐567. - PubMed

[8] Kakoly NS, Earnest A, Teede HJ, Moran LJ, Joham AE. The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome. Diabetes Care. 2019;42:560‐567. - PubMed

[9] Joham A, Teede H, Ranasinha S, Zoungas S, Boyle J. Infertility and assisted reproductive technology use in women with polycystic ovary syndrome: data from the Australian longitudinal women's health study. J Women's Health. 2015;24:299‐307. - PubMed

[10] Joham A, Teede H, Ranasinha S, Zoungas S, Boyle J. Infertility and assisted reproductive technology use in women with polycystic ovary syndrome: data from the Australian longitudinal women's health study. J Women's Health. 2015;24:299‐307. - PubMed

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Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

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Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

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Conflict of interest statement

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