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Comment
. 2022 May 19;82(10):1786-1787.
doi: 10.1016/j.molcel.2022.05.001.

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Paul A Cobine  1 , Donita C Brady  2
Affiliations
Free article
Comment

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Paul A Cobine et al. Mol Cell. .
Free article

Abstract

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.

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Conflict of interest statement

Declaration of interests D.C.B. holds ownership in Merlon Inc. and Elaeis Therapeutics, is an inventor on the patent application 20150017261 entitled “Methods of treating and preventing cancer by disrupting the binding of copper in the MAP kinase pathway,” and is a member of the Molecular Cell advisory board. P.A.C. reports no competing interests.

Comment on

  • Copper induces cell death by targeting lipoylated TCA cycle proteins.
    Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR. Tsvetkov P, et al. Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529. Epub 2022 Mar 17. Science. 2022. PMID: 35298263 Free PMC article.

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