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Comment
. 2022 Jun 13;40(6):597-599.
doi: 10.1016/j.ccell.2022.04.017. Epub 2022 May 19.

Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells

Jessica K Mandula  1 , Paulo C Rodriguez  2
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Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells

Jessica K Mandula et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Long et al. demonstrate that tumors can reprogram erythroid progenitors into myeloid-erythroid cells that promote immunosuppression. Erythroid-differentiated myeloid cells (EDMCs) expand in cancer-bearing individuals, resemble the functionality of myeloid-derived suppressor cells (MDSCs), and correlate with poor response to immune-checkpoint inhibitors (ICIs) and tumor-related anemia.

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Declaration of interests The authors declare no competing interests.

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