Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 5;68(3):fmac037.
doi: 10.1093/tropej/fmac037.

Predictors of Bronchopulmonary Dysplasia in 625 Neonates with Respiratory Distress Syndrome

Yue Tao  1 , Xiao Han  1 , Wan-Liang Guo  1
Affiliations

Predictors of Bronchopulmonary Dysplasia in 625 Neonates with Respiratory Distress Syndrome

Yue Tao et al. J Trop Pediatr. .

Abstract

Objective: This study was designed to investigate the predictors of bronchopulmonary dysplasia in neonates with respiratory distress syndrome.

Methods: This was a single-center retrospective cohort study conducted between 1 January 2015 and 31 December 2020. A total of 625 neonates with respiratory distress syndrome (RDS) were enrolled. Demographic data, clinical presentations, complications and related treatment information were collected and analyzed. We used bivariate and multivariate logistic-regression analyses to determine significant predictors of bronchopulmonary dysplasia (BPD) in RDS neonates.

Results: In these 625 neonates, 102 (16.3%) of them developed BPD. Bivariate analysis and multivariate logistic-regression analyses revealed that birthweight, gestational age under 32 weeks, duration of oxygen therapy over 10 days, asphyxia, patent ductus arteriosus, transfusion of red blood cells (packed red blood cells) and surfactant use were significantly associated with the development of BPD.

Conclusion: Birthweight, gestational age <32 weeks, total duration of oxygen therapy >10 days, asphyxia, patent ductus arteriosus, need for red blood cell infusion, and the use of pulmonary surfactant were important predictors of BPD in neonates with RDS.

Keywords: bronchopulmonary dysplasia; neonate; respiratory distress syndrome; risk factors.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
The flow chart of the study.
Fig. 2.
Fig. 2.
Receiver operating characteristics curves for the prediction model of bronchopulmonary dysplasia in neonate with respiratory distress syndrome (AUC = 0.818).
Fig. 3.
Fig. 3.
Comparison of different modes of respiratory support between BPD and non-BPD group.
See this image and copyright information in PMC

References

    1. Lignelli E, Palumbo F, Myti D, et al.Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 2019;317:L832–87. - PubMed
    1. Arjaans S, Haarman MG, Roofthooft M, et al.Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age. Arch Dis Child Fetal Neonatal Ed 2021;106:45–50. - PMC - PubMed
    1. Principi N, Di Pietro GM, Esposito S.. Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies. J Transl Med 2018;16:36. - PMC - PubMed
    1. Northway WJ, Rosan RC, Porter DY.. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967;276:357–68. - PubMed
    1. Higgins RD, Jobe AH, Koso-Thomas M, et al.Bronchopulmonary dysplasia: executive summary of a workshop. J Pediatr 2018;197:300–8. - PMC - PubMed

MeSH terms