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Comment
. 2022 Jun;101(6):1110-1112.
doi: 10.1016/j.kint.2022.04.008.

Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?

Olivia Lenoir  1 , Pierre-Louis Tharaux  2
Affiliations
Comment

Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?

Olivia Lenoir et al. Kidney Int. 2022 Jun.

Abstract

Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation of albuminuria and proteinuria was observed in 4 children treated with cinacalcet. Here we discuss the potential mechanisms whereby CaSR displays a favorable effect in podocytes and the context in which calcimimetics may alleviate nephrotic syndrome.

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  • The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice.
    Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen MM, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J. Mühlig AK, et al. Kidney Int. 2022 Jun;101(6):1186-1199. doi: 10.1016/j.kint.2022.01.036. Epub 2022 Mar 7. Kidney Int. 2022. PMID: 35271934

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