Comment
doi: 10.1016/j.tem.2022.05.001.
Epub 2022 May 19.
Shifting metabolism to increase lifespan
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- PMID: 35597712
- DOI: 10.1016/j.tem.2022.05.001
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Comment
Shifting metabolism to increase lifespan
Trends Endocrinol Metab.
2022 Aug.
Abstract
Lionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.
Keywords: C. elegans; fructose; glucose; lifespan; metabolic shift; mitochondrial protein import.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no conflicts of interest.
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