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Comment
. 2022 Aug;33(8):533-535.
doi: 10.1016/j.tem.2022.05.001. Epub 2022 May 19.

Shifting metabolism to increase lifespan

João Pessoa  1
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Shifting metabolism to increase lifespan

João Pessoa. Trends Endocrinol Metab. 2022 Aug.

Abstract

Lionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.

Keywords: C. elegans; fructose; glucose; lifespan; metabolic shift; mitochondrial protein import.

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Conflict of interest statement

Declaration of interests The author declares no conflicts of interest.

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