A novel YAP1-MAML2 fusion in an adult supra-tentorial ependymoma, YAP1-fused

Arnault Tauziède-Espariat^{1

2

3}, Aurore Siegfried^{4

5

6}, Yvan Nicaise⁵, Dominique Figarella-Branger^{7

8}, Romain Appay^{7

8}, Suhan Senova⁹, Dorian Bochaton¹⁰, Lauren Hasty¹¹, Anna Martin¹², Fabrice Chrétien^{11

13}, Alice Métais^{11

14

13}, Pascale Varlet^{11

14

13}, Emmanuelle Uro-Coste^{4

5

6}; RENOCLIP-LOC

Affiliations

¹ Department of Neuropathology, GHU Paris, Psychiatry and Neuroscience, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
² INSERM, U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Université de Paris, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
³ Université de Paris, Paris, France. a.tauziede-espariat@ghu-paris.fr.
⁴ Department of Pathology, Toulouse University Hospital, Toulouse, France.
⁵ INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
⁶ Université Paul Sabatier, Toulouse III, Toulouse, France.
⁷ Service d'Anatomie Pathologique et de Neuropathologie, APHM, CHU Timone, Marseille, France.
⁸ CNRS, INP, Inst Neurophysiopathol, Aix-Marseille Univ, Marseille, France.
⁹ Department of Neurosurgery, Mondor Hospital, 94010, Créteil, France.
¹⁰ Laboratory of Somatic Genetics, Institut Curie Hospital, Paris, France.
¹¹ Department of Neuropathology, GHU Paris, Psychiatry and Neuroscience, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France.
¹² Department of Neuroradiology, Mondor Hospital, 94010, Créteil, France.
¹³ Université de Paris, Paris, France.
¹⁴ INSERM, U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Université de Paris, 75014, Paris, France.

Arnault Tauziède-Espariat et al. Brain Tumor Pathol. 2022 Oct.

. 2022 Oct;39(4):240-242.

doi: 10.1007/s10014-022-00439-0. Epub 2022 May 22.

¹ Department of Neuropathology, GHU Paris, Psychiatry and Neuroscience, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
² INSERM, U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Université de Paris, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
³ Université de Paris, Paris, France. a.tauziede-espariat@ghu-paris.fr.
⁴ Department of Pathology, Toulouse University Hospital, Toulouse, France.
⁵ INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
⁶ Université Paul Sabatier, Toulouse III, Toulouse, France.
⁷ Service d'Anatomie Pathologique et de Neuropathologie, APHM, CHU Timone, Marseille, France.
⁸ CNRS, INP, Inst Neurophysiopathol, Aix-Marseille Univ, Marseille, France.
⁹ Department of Neurosurgery, Mondor Hospital, 94010, Créteil, France.
¹⁰ Laboratory of Somatic Genetics, Institut Curie Hospital, Paris, France.
¹¹ Department of Neuropathology, GHU Paris, Psychiatry and Neuroscience, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France.
¹² Department of Neuroradiology, Mondor Hospital, 94010, Créteil, France.
¹³ Université de Paris, Paris, France.
¹⁴ INSERM, U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Université de Paris, 75014, Paris, France.

No abstract available

References

1. Ellison DW, Aldape KD, Capper D, Fouladi M, Gilbert MR, Gilbertson RJ et al (2020) cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. Brain Pathol 30(5):863–866 - PubMed - PMC
1. Andreiuolo F, Varlet P, Tauziède-Espariat A, Jünger ST, Dörner E, Dreschmann V et al (2019) Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol 29(2):205–216 - DOI
1. Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L et al (2019) YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun 10(1):3914 - DOI
1. Wang J, Wang L, Fu L, Li QC, Qiu XS, Wang EH et al (2021) Supratentorial ependymoma with YAP1:FAM118B fusion: a case report. Neuropathology 41(2):133–138 - DOI
1. Gessi M, Giagnacovo M, Modena P, Elefante G, Gianno F, Buttarelli FR et al (2019) Role of immunohistochemistry in the identification of supratentorial C11ORF95-RELA fused ependymoma in routine neuropathology. Am J Surg Pathol 43(1):56–63 - DOI