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Review
. 2022 Oct;163(4):840-851.
doi: 10.1053/j.gastro.2022.05.031. Epub 2022 May 19.

Natural History of Alcohol-Associated Liver Disease: Understanding the Changing Landscape of Pathophysiology and Patient Care

Jasmohan S Bajaj  1 , Laura E Nagy  2
Affiliations
Review

Natural History of Alcohol-Associated Liver Disease: Understanding the Changing Landscape of Pathophysiology and Patient Care

Jasmohan S Bajaj et al. Gastroenterology. 2022 Oct.

Abstract

Alcohol use and consequent liver disease are major burdens that have worsened during the COVID-19 pandemic. There are several facets to the pathophysiology and clinical consequences of alcohol-use disorder (AUD) and progression to alcohol-associated liver disease (ALD) that require a concerted effort by clinicians and translational and basic science investigators. Several recent advances from bedside to bench and bench to bedside have been made in ALD. We focused this review on a case-based approach that provides a human context to these important advances across the spectrum of ALD.

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Conflict of interest statement

Conflict of interest: None for any author

Figures

Figure 1:
Figure 1:
Overlaps between symptoms in inpatients with cirrhosis and alcohol use disorder (AUD) (adapted from Davis et al)
Figure 2:
Figure 2:
Proposed flowchart for evaluation of altered mental status in inpatients with alcohol-associated cirrhosis. (adapted from Davis et al)
Figure 3:
Figure 3:
Proposed flowchart to work up outpatients with alcohol-associated cirrhosis (adapted from Davis et al)
See this image and copyright information in PMC

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