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Review
. 2022 May 12:2022:2650342.
doi: 10.1155/2022/2650342. eCollection 2022.

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

Callie Travis  1 , Priya S Srivastava  2 , Thomas J Hawke  3 , Evangelia Kalaitzoglou  4   5
Affiliations
Review

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

Callie Travis et al. J Diabetes Res. .

Abstract

Type 1 diabetes is associated with complications affecting muscle and bone, with diabetic bone disease and diabetic myopathy becoming increasingly reported in the past few decades. This review is aimed at succinctly reviewing the literature on the current knowledge regarding these increasingly identified and possibly interconnected complications on the musculoskeletal system. Furthermore, this review summarizes several nonmechanical factors that could be mediating the development and progression of premature musculoskeletal decline in this population and discusses preventative measures to reduce the burden of diabetes on the musculoskeletal system.

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Conflict of interest statement

The authors confirm that they have no conflicts of interest to declare for this publication.

Figures

Figure 1
Figure 1
Common underlying mechanisms of diabetic bone disease and diabetic myopathy in type 1 diabetes (created with http://BioRender.com/).
See this image and copyright information in PMC

References

    1. Type 1 Diabetes Statistics. https://beyondtype1.org/type-1-diabetes-statistics/
    1. Dabelea D., Mayer-Davis E. J., Saydah S., et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. Journal of the American Medical Association . 2014;311(17):1778–1786. doi: 10.1001/jama.2014.3201. - DOI - PMC - PubMed
    1. Mobasseri M., Shirmohammadi M., Amiri T., Vahed N., Hosseini Fard H., Ghojazadeh M. Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promotion Perspective . 2020;10(2):98–115. doi: 10.34172/hpp.2020.18. - DOI - PMC - PubMed
    1. Khan T. S., Fraser L. A. Type 1 diabetes and osteoporosis: from molecular pathways to bone phenotype. Journal of Osteoporosis . 2015;2015:8. doi: 10.1155/2015/174186.174186 - DOI - PMC - PubMed
    1. Hough F. S., Pierroz D. D., Cooper C., Ferrari S. L., Bone I. C., Diabetes Working Group Mechanisms in endocrinology: mechanisms and evaluation of bone fragility in type 1 diabetes mellitus. European Journal of Endocrinology . 2016;174(4):R127–R138. doi: 10.1530/EJE-15-0820. - DOI - PubMed