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Review
. 2022 May 18;15(5):820-827.
doi: 10.18240/ijo.2022.05.20. eCollection 2022.

Inflammation and dry eye disease-where are we?

Srinivas K Rao  1 , Rishi Mohan  2 , Nikhil Gokhale  3 , Himanshu Matalia  4 , Paras Mehta  5
Affiliations
Review

Inflammation and dry eye disease-where are we?

Srinivas K Rao et al. Int J Ophthalmol. .

Abstract

The presence of inflammation in dry eye disease (DED) results in increased patient symptomatology, ocular surface damage and worsening tear dysfunction. It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease. This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED, inflammation and meibomian gland dysfunction (MGD). The clinical evaluation of eyes with such changes, markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed.

Keywords: dry eye disease; inflammation; meibomian gland dysfunction; ocular surface disease; vicious cycle.

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Figures

Figure 1
Figure 1. Vicious cycles of DED, inflammation and MGD and their relationships.
See this image and copyright information in PMC

References

    1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) Ocul Surf. 2007;5(2):75–92. - PubMed
    1. Gipson IK. The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2007;48(10):4390; 4391–4398. - PMC - PubMed
    1. Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K, West S. Prevalence of dry eye among the elderly. Am J Ophthalmol. 1997;124(6):723–728. - PubMed
    1. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007) Ocul Surf. 2007;5(2):93–107. - PubMed
    1. Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, Lemp MA, Sullivan DA. The international workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci. 2011;52(4):1922–1929. - PMC - PubMed

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