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Review
. 2022;34(4):2173-2185.
doi: 10.1007/s10811-022-02749-4. Epub 2022 May 17.

Phlorotannins-bioactivity and extraction perspectives

Lekshmi R G Kumar  1 , Preethy Treesa Paul  1 , K K Anas  1 , C S Tejpal  1 , N S Chatterjee  1 , T K Anupama  2 , Suseela Mathew  1 , C N Ravishankar  1
Affiliations
Review

Phlorotannins-bioactivity and extraction perspectives

Lekshmi R G Kumar et al. J Appl Phycol. 2022.

Abstract

Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sustainable techniques such as supercritical fluid extraction, microwave assisted extraction, enzyme assisted extraction, extraction using deep eutectic solvents etc. are being explored currently for production of phlorotannin-rich extracts. In spite of such well documented bioactivities, very few phlorotannin-based nutraceuticals are available commercially which highlights the significance of generating consumer awareness about their physiological benefits. However, for industry level commercialization accurate quantification of phlorotannins with respect to the different classes is vital requiring sophisticated analytical techniques such as mass spectrometry, 1H-NMR spectroscopy etc. owing to the wide structural diversity. This review summarizes the extraction and bioactivities of phlorotannins based on the findings of in vivo and in vitro studies.

Keywords: Anti-proliferative; Anti-viral; Histamine; Hyaluronidase; Lipopolysaccharide; Melanosis; Neurodegeneration; Nitric oxide; Phloroethols; Supercritical fluid extraction.

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Conflict of interest statement

Competing interestsThe authors have no competing interests to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Bioactivities of phlorotannins
Fig. 2
Fig. 2
Phlorotannin Extraction methods
See this image and copyright information in PMC

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