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. 2022 May 10:24:90-99.
doi: 10.1016/j.jmsacl.2022.05.001. eCollection 2022 Apr.

The triple quadrupole: Innovation, serendipity and persistence

Richard A Yost  1
Affiliations

The triple quadrupole: Innovation, serendipity and persistence

Richard A Yost. J Mass Spectrom Adv Clin Lab. .
No abstract available

Keywords: Concepts; History; MS/MS; Perspectives; Triple quadrupole.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Part of a mass spectrum between m/z 14 and 26 showing a variety of diffuse (metastable) peaks; adapted from .
Fig. 2
Fig. 2
Scale drawing (top view) of the triple quadrupole MS/MS instrument proposed to the NSF and ONR. .
Fig. 3
Fig. 3
Jim Morrison at the controls of the LaTrobe triple quadrupole instrument in 1977. .
Fig. 4
Fig. 4
MS/MS spectrum of m/z 78 of a trace contaminant (benzene) in a sample of cyclohexanone, obtained on the LaTrobe triple quadrupole instrument.
Fig. 5
Fig. 5
Vacuum chambers (A) and electronics (B) of the triple quadrupole MS/MS instrument constructed at MSU.
Fig. 6
Fig. 6
Scan modes for MS/MS (a daughter or product ion scan) and for MS on a triple quadrupole instrument.
Fig. 7
Fig. 7
Growth of analytical MS/MS papers at the ASMS Annual Conference from 1976 through 1988.
Fig. 8
Fig. 8
Complete MS/MS data set for i-propanol .
Fig. 9
Fig. 9
The effect of increasing numbers of stages of analysis on signal, chemical noise, and signal-to-noise ratio. Adapted from .
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See this image and copyright information in PMC

References

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    1. R.G. Cooks, J.H. Beynon, R.M. Caprioli, G.R. Lecter, Metastable Ions, Elsevier, Amsterdam, Figure 15 (p. 39), 1973.
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    1. Cooks R.G., Beynon J.H. Metastable ions and ion kinetic energy spectrometry: the development of a new research area. J. Chem. Ed. 1974;51:437–443. doi: 10.1021/ed051p437. - DOI
    1. Jennings K.R. The changing impact of the collision-induced decomposition of ions on mass spectrometry. Int. J. Mass Spectrom. 2000;200:479–493. doi: 10.1016/S1387-3806(00)00325-0. - DOI

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