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. 2022 Jan-Dec:28:10760296221102929.
doi: 10.1177/10760296221102929.

Clinical Efficacy of Soluble Thrombomodulin, Tissue Plasminogen Activator Inhibitor complex, Thrombin-Antithrombin complex,α2-Plasmininhibitor-Plasmin complex in Pediatric Sepsis

Juanzhen Li  1 , Jingyi Zhou  2 , Hong Ren  1 , Teng Teng  1 , Biru Li  1 , Ying Wang  1 , Long Xiang  1   3
Affiliations

Clinical Efficacy of Soluble Thrombomodulin, Tissue Plasminogen Activator Inhibitor complex, Thrombin-Antithrombin complex,α2-Plasmininhibitor-Plasmin complex in Pediatric Sepsis

Juanzhen Li et al. Clin Appl Thromb Hemost. 2022 Jan-Dec.

Abstract

Objective: To investigated the clinical efficacy of Soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (t-PAI·C),thrombin-antithrombin complex (TAT),α2-plasmininhibitor-plasmin complex (PIC) in pediatric sepsis and pediatrics sepsis-induced coagulopathy (pSIC).

Methods: We prospectively collected patient data with sepsis diagnosed in the PICU of Shanghai Children's Medical Center from June 2019 to June 2021. sTM,t-PAI·C, TAT,PIC and classical coagulation laboratory tests (CCTs) were evaluated on the day of sepsis diagnosis.

Results: Fifty-nine children were enrolled, There were significant differences in t-PAI·C (P = 0.001), Plt (P < 0.001), PT (P < 0.001), INR (P < 0.001), aPTT (P < 0.001), and TT (P = 0.048) between the pSIC and non-pSIC groups, logistic regression analysis showed that Plt (P = 0.032) was an independent risk factor for pSIC. Logistic regression analysis showed that sTM (P = 0.007) and Plt (P = 0.016) were independent risk factors for the outcome in pediatrics sepsis following discharge. The AUC of sTM combined with Plt on the mortality outcome of children with sepsis at discharge was 0.889 (95%CI: 0.781,0.956). which was better than that for PRISM III (AUC, 0.723), pSOFA (AUC, 0.764), and blood Lac (AUC, 0.717) when sepsis was diagnosed in the PICU.

Conclusions: The t-PAI·C increased in children with pSIC. The prediction of sepsis outcome using sTM combined with Plt was better than with PRISM III, pSOFA, or Lac.Further research is still needed in the future to explore the clinical value of sTM, TAT, PIC, and t-PAI·C in diagnosis and outcome of pediatrics sepsis and pSIC.

Keywords: Children‌; Endothelial cell injury; Novel coagulation markers; Sepsis-induced coagulopathy; ‌Sepsis.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison of t-PAI·C between patients with pSIC and non-pSIC groups Secondary outcomes in the pSIC and non-pSIC groups
Figure 2.
Figure 2.
A.Comparison of sTM between patients with Survivla and Non-Survival groups; B. Comparison of TAT between patients with Survivla and Non-Survival groups
Figure 3.
Figure 3.
AU-ROC of sTM combined with Plt,P-MODS,PRISM III, pSOFA, Lac in predicting the mortality outcome due to sepsis at discharge.
See this image and copyright information in PMC

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